Article
Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion.
PloS one - 1 Jan 2009
Newhouse Stephen, Farrall Martin, Wallace Chris, Hoti Mimoza, Burke Beverley, Howard Philip, Onipinla Abiodun, Lee Kate, Shaw-Hawkins Sue, Dobson Richard, Brown Morris, Samani Nilesh J, Dominiczak Anna F, Connell John M, Lathrop G Mark, Kooner Jaspal, Chambers John, Elliott Paul, Clarke Robert, Collins Rory, Laan Maris, Org Elin, Juhanson Peeter, Veldre Gudrun, Viigimaa Margus, Eyheramendy Susana, Cappuccio Francesco P, Ji Chen, Iacone Roberto, Strazzullo Pasquale, Kumari Meena, Marmot Michael, Brunner Eric, Caulfield Mark, Munroe Patricia B
Abstract excerpt
WNK1--a serine/threonine kinase involved in electrolyte homeostasis and blood pressure (BP) control--is an excellent candidate gene for essential hypertension (EH). We and others have previously reported association between WNK1 and BP variation. Using tag SNPs (tSNPs) that capture 100% of common WNK1 variation in HapMap, we aimed to replicate our findings with BP and to test for association with phenotypes...
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