Article
New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability.
Nucleic acids research - 1 Aug 1999
Ouspenski I I, Elledge S J, Brinkley B R
Abstract excerpt
Phenotypes produced by gene overexpression may provide important clues to gene function. Here, we have performed a search for genes that affect chromo-some stability when overexpressed in the budding yeast Saccharomyces cerevisiae. We have obtained clones encompassing 30 different genes. Twenty-four of these genes have been previously characterized. Most of them are involved in chromatin dynamics, cell cycle...
Topics
- Aneuploidy
- Cell Cycle
- Chromosome Segregation
- Cloning, Molecular
- Conserved Sequence
- DNA Damage
- DNA Replication
- DNA, Fungal
- Gene Deletion
- Gene Dosage
- Gene Expression