Article
New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability.
Nucleic acids research - 1 Aug 1999
Ouspenski I I, Elledge S J, Brinkley B R
Abstract excerpt
Phenotypes produced by gene overexpression may provide important clues to gene function. Here, we have performed a search for genes that affect chromo-some stability when overexpressed in the budding yeast Saccharomyces cerevisiae. We have obtained clones encompassing 30 different genes. Twenty-four of these genes have been previously characterized. Most of them are involved in chromatin dynamics, cell cycle...
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