Article
Small GTPase R-Ras regulates integrity and functionality of tumor blood vessels.
Cancer cell - 14 Aug 2012
Sawada Junko, Urakami Takeo, Li Fangfei, Urakami Akane, Zhu Weiquan, Fukuda Minoru, Li Dean Y, Ruoslahti Erkki, Komatsu Masanobu
Abstract excerpt
We show that R-Ras, a small GTPase of the Ras family, is essential for the establishment of mature, functional blood vessels in tumors. The genetic disruption of R-Ras severely impaired the maturation processes of tumor vessels in mice. Conversely, the gain of function of R-Ras improved vessel structure and blood perfusion and blocked plasma leakage by enhanced endothelial barrier function and pericyte...
Topics
- Adherens Junctions
- Animals
- Antigens, CD
- Basic Helix-Loop-Helix Transcription Factors
- Blood Vessels
- Cadherins
- Cell Hypoxia
- Down-Regulation
- Endocytosis
- Endothelial Cells
- Humans
- Hypoxia-Inducible Factor-Proline Dioxygenases
- Mice