Article
Blood vessels restrain pancreas branching, differentiation and growth.
Development (Cambridge, England) - 1 Nov 2011
Magenheim Judith, Ilovich Ohad, Lazarus Alon, Klochendler Agnes, Ziv Oren, Werman Roni, Hija Ayat, Cleaver Ondine, Mishani Eyal, Keshet Eli, Dor Yuval
Abstract excerpt
How organ size and form are controlled during development is a major question in biology. Blood vessels have been shown to be essential for early development of the liver and pancreas, and are fundamental to normal and pathological tissue growth. Here, we report that, surprisingly, non-nutritional signals from blood vessels act to restrain pancreas growth. Elimination of endothelial cells increases the size of...
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