Article
FoxM1 promotes breast tumorigenesis by activating PDGF-A and forming a positive feedback loop with the PDGF/AKT signaling pathway.
Oncotarget - 10 May 2015
Yu Guanzhen, Zhou Aidong, Xue Jianfei, Huang Chen, Zhang Xia, Kang Shin-Hyuk, Chiu Wen-Tai, Tan Christina, Xie Keping, Wang Jiejun, Huang Suyun
Abstract excerpt
The autocrine platelet-derived growth factor (PDGF)/PDGF receptor (PDGFR) signaling pathway promotes breast cancer tumorigenesis, but the mechanisms for its dysregulation in breast cancer are largely unknown. In the study, we identified PDGF-A as a novel transcriptional target of FoxM1. FoxM1 directly binds to two sites in the promoter of PDGF-A and activates its transcription. Mutation of these FoxM1-binding...
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