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Article

Molecular Evidence Supporting Field Effect in Urothelial Carcinogenesis

15 Sept 2005

Abstract excerpt

PURPOSE: Human urothelial carcinoma is thought to arise from a field change that affects the entire urothelium. Multifocality of urothelial carcinoma is a common finding at endoscopy and surgery. Whether these coexisting tumors arise independently or are derived from the same tumor clone is uncertain. Molecular analysis of microsatellite alterations and X-chromosome inactivation status in the cells from each...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 16166427
DOI: 10.1158/1078-0432.ccr-05-0891

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