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Article

The origin of bladder cancer from mucosal field effects

7 Jun 2022

Abstract excerpt

Whole-organ mapping was used to study molecular changes in the evolution of bladder cancer from field effects. We identified more than 100 dysregulated pathways, involving immunity, differentiation, and transformation, as initiators of carcinogenesis. Dysregulation of interleukins signified the involvement of inflammation in the incipient phases of the process. An aberrant methylation/expression of multiple HOX...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 35747385
DOI: 10.1016/j.isci.2022.104551

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