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Article

Clonal origin of bladder cancer.

The New England journal of medicine - 12 Mar 1992

Sidransky D, Frost P, Von Eschenbach A, Oyasu R, Preisinger A C, Vogelstein B

Abstract excerpt

BACKGROUND: Patients with cancer of the urinary bladder often present with metachronous tumors, appearing at different times and at different sites in the bladder. This observation has been attributed to a "field defect" in the bladder that allows the independent transformation of epithelial cells at a number of sites. We tested this hypothesis using molecular genetic techniques. METHODS: We examined 13 tumors...

Topics

Alleles
Cell Transformation, Neoplastic
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 9
Clone Cells
Dosage Compensation, Genetic
Female
Humans
Urinary Bladder Neoplasms

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Identifiers

PMID: 1445507
DOI: 10.1056/NEJM199203123261104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1445507-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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