Article
Altered Kupffer cell function in biliary obstruction.
Surgery - 1 Aug 2005
Minter Rebecca M, Fan Ming-Hui, Sun Jianmin, Niederbichler Andreas, Ipaktchi Kyros, Arbabi Saman, Hemmila Mark R, Remick Daniel G, Wang Stewart C, Su Grace L
Abstract excerpt
BACKGROUND: An altered Kupffer cell (KC) response is thought to be responsible for the characteristic phenotype observed after biliary obstruction: a phenotype marked by a defect in the hepatic reticuloendothelial system and a hypersensitivity to endotoxin. Few studies, however, have directly examined KC function. We have sought to define the specific alterations in function and phenotype that occur in the KC...
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