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Article

Pivotal roles of Kupffer cells in the progression and regression of DDC-induced chronic cholangiopathy.

Scientific reports - 23 Apr 2018

Jemail Leila, Miyao Masashi, Kotani Hirokazu, Kawai Chihiro, Minami Hirozo, Abiru Hitoshi, Tamaki Keiji

Abstract excerpt

Kupffer cells (KCs) are key players in maintaining tissue homeostasis and are involved in various liver diseases. However, the roles of KCs in the pathogenesis of cholangiopathy are largely unknown. We aimed to investigate the precise roles of KCs in both the progression and regression phases of the 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-induced cholangiopathy model. In the early phase of DDC-induced...

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Source

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Identifiers

PMID: 29686325
DOI: 10.1038/s41598-018-24825-x
PMCID: PMC5913224

Genes

DDC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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