Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Macrophage phenotype during cholestatic injury and repair: the persistent inflammatory response.

Journal of pediatric surgery - 1 Jan 2001

Roggin K K, Kim J C, Kurkchubasche A G, Papa E F, Vezeridis A M, Tracy T F

Abstract excerpt

BACKGROUND/PURPOSE: Biliary decompression for congenital or acquired obstruction (eg, biliary atresia) does not uniformly lead to liver repair, restore function, or prevent cholangitis. The authors hypothesize that failed repair is caused by altered macrophage (Mo) phenotypes central to an ongoing inflammatory and fibrogenic response. METHODS: In adult rats, biliary obstruction was performed by suspension of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Inflammatory Agents
Share to Bilirubin
Share to Cholestasis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gadolinium

Share to Immunoenzyme Techniques

Share to Kupffer Cells

Share to Macrophage Activation

Share to Rats, Sprague-Dawley

Source

Identifiers

PMID: 11150470
DOI: 10.1053/jpsu.2001.20059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Macrophage phenotype during cholestatic injury and repair: the persistent inflammatory response.PMID 11150470Read ↗

Macrophage Phenotype and Function in Liver Disorder.Semantic proximity Read ↗

Macrophage Phenotype in Liver Injury and RepairSemantic proximity Read ↗

The inflammatory response in pediatric biliary disease: macrophage phenotype and distribution.Semantic proximity Read ↗

Macrophage heterogeneity in liver injury and fibrosisSemantic proximity Read ↗

An Eye on Kupffer Cells: Development, Phenotype and the Macrophage Niche.Semantic proximity Read ↗

Mac the knife? Macrophages- the double-edged sword of hepatic fibrosis.Semantic proximity Read ↗

Altered Kupffer cell function in biliary obstruction.Semantic proximity Read ↗

Hepatocytes, Rather than Cholangiocytes, Can Be the Major Source of Primitive Ductules in the Chronically Injured Mouse LiverSemantic proximity Read ↗

Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice.Semantic proximity Read ↗

Kupffer Cells Undergo Fundamental Changes during the Development of Experimental NASH and Are Critical in Initiating Liver Damage and InflammationSemantic proximity Read ↗

Selective activation of Toll-like receptor 7 in activated hepatic stellate cells may modulate their profibrogenic phenotype.Semantic proximity Read ↗

Transcriptional profiling of pediatric cholestatic livers identifies three distinct macrophage populationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.