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Article

Alterations in tumor necrosis factor-alpha expression by hepatic macrophages following acute cholestatic liver injury.

Shock (Augusta, Ga.) - 1 Feb 1996

Fox E S, Tracy T F

Abstract excerpt

The liver is unique for its large resident macrophage (HM phi) population as a potential source of immunoregulatory cytokines. The present study was designed to determine HM phi function in a rat model of cholestasis (CBDL). Northern blot analysis of TNF-alpha mRNA showed a profound difference in the dose response to bacterial lipopolysaccharide (LPS) between sham and CBDL HM phi. Sham HM phi demonstrated an...

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Identifiers

PMID: 8705387
DOI: 10.1097/00024382-199602000-00005

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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