Article
Macrophage Phenotype and Function in Liver Disorder.
Frontiers in immunology - 1 Jan 2019
Dou Lang, Shi Xiaomin, He Xiaoshun, Gao Yifang
Abstract excerpt
Hepatic macrophages are a remarkably heterogeneous population consisting of self-renewing tissue-resident phagocytes, termed Kupffer cells (KCs), and recruited macrophages derived from peritoneal cavity as well as the bone marrow. KCs are located in the liver sinusoid where they scavenge the microbe from the portal vein to maintain liver homeostasis. Liver injury may trigger hepatic recruitment of peritoneal...
Topics
- Biomarkers
- Cell Communication
- Cytokines
- Disease Management
- Disease Susceptibility
- Humans
- Immunophenotyping
- Kupffer Cells
- Liver Diseases
- Macrophages
- Molecular Targeted Therapy
- Phenotype