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Article

Development of a cytokine-producing immortalized murine Kupffer cell line.

Cytokine - 1 Dec 2014

Wang Zheng-Yu, Burlak Christopher, Klaunig James E, Kamendulis Lisa M

Abstract excerpt

Kupffer cells (KC) play a critical role in both liver physiology and the pathogenesis of various liver diseases. Isolated primary KC have a limited lifespan in culture, and due to the relatively low number obtained, limit their study in vitro. Here, a cytokine-producing immortalized KC (ImKC) line was established from transgenic mice that express the thermolabile mutant tsA58 of the Simian virus 40 large T...

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Source

Identifiers

PMID: 25138015
DOI: 10.1016/j.cyto.2014.07.251

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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