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Article

Lipopolysaccharide Lowers Cholesteryl Ester Transfer Protein by Activating F4/80+Clec4f+Vsig4+Ly6C- Kupffer Cell Subsets.

Journal of the American Heart Association - 10 Mar 2018

van der Tuin Sam J L, Li Zhuang, Berbée Jimmy F P, Verkouter Inge, Ringnalda Linda E, Neele Annette E, van Klinken Jan B, Rensen Sander S, Fu Jingyuan, de Winther Menno P J, Groen Albert K, Rensen Patrick C N, Willems van Dijk Ko, Wang Yanan

Abstract excerpt

BACKGROUND: Lipopolysaccharide (LPS) decreases hepatic CETP (cholesteryl ester transfer protein) expression albeit that the underlying mechanism is disputed. We recently showed that plasma CETP is mainly derived from Kupffer cells (KCs). In this study, we investigated the role of KC subsets in the mechanism by which LPS reduces CETP expression. METHODS AND RESULTS: In CETP-transgenic mice, LPS markedly decreased...

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Share to Antigens, Ly
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lectins, C-Type

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Source

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Identifiers

PMID: 29525783
DOI: 10.1161/JAHA.117.008105
PMCID: PMC5907564

Genes

CETP
VSIG4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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