Article
Gene mapping with pooled samples on three genotyping platforms.
Molecular and cellular probes - 1 Dec 2005
Rautanen Anna, Zucchelli Marco, Mäkelä Siru, Kere Juha
Abstract excerpt
We have evaluated three genotyping techniques to detect allelic association between single nucleotide polymorphisms (SNPs) and disease loci by using pooled DNA samples. The use of DNA pools instead of individual samples saves considerably time, DNA quantity, and reagent costs. The methods that were compared were PCR-restriction fragment length polymorphism (PCR-RFLP), Single nucleotide primer extension, and...
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