Estimation of allele frequency in pooled DNA by using PCR-RFLP combined with microchip electrophoresis.

Abstract excerpt

Biallelic marker, most commonly single nucleotide polymorphism (SNP), is widely utilized in genetic association analysis, which can be speeded up by estimating allele frequency in pooled DNA instead of individual genotyping. Several methods have shown high accuracy and precision for allele frequency estimation in pools. Here, we explored PCR restriction fragment length polymorphism (PCR-RFLP) combined with...

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