Article
High-throughput SNP detection by using DNA pooling and denaturing high performance liquid chromatography (DHPLC).
Human genetics - 1 Nov 2000
Wolford J K, Blunt D, Ballecer C, Prochazka M
Abstract excerpt
One of the critical steps in the positional cloning of a complex disease gene involves association analysis between a phenotype and a set of densely spaced diallelic markers, typically single nucleotide repeats (SNPs), covering the region of interest. However, the effort and cost of detecting sufficient numbers of SNPs across relatively large physical distances represents a significant rate-limiting step. We have...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.