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Article

Cyclooxygenase-1 haplotype modulates platelet response to aspirin.

Journal of thrombosis and haemostasis : JTH - 1 Oct 2005

Maree A O, Curtin R J, Chubb A, Dolan C, Cox D, O'Brien J, Crean P, Shields D C, Fitzgerald D J

Abstract excerpt

BACKGROUND: Aspirin (acetylsalicylic acid) irreversibly inhibits platelet cyclooxygenase (COX)-1, the enzyme that converts arachidonic acid (AA) to the potent platelet agonist thromboxane (TX) A2. Despite clear benefit from aspirin in patients with cardiovascular disease (CAD), evidence of heterogeneity in the way individuals respond has given rise to the concept of 'aspirin resistance.' AIMS: To evaluate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16150050
DOI: 10.1111/j.1538-7836.2005.01555.x

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cyclooxygenase-1 haplotype modulates platelet response to aspirin.PMID 16150050Read ↗

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Genetic variation in cyclooxygenase 1: Effects on response to aspirinSemantic proximity Read ↗

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