Article
Genetic determinants of response to aspirin: appraisal of 4 candidate genes.
Thrombosis research - 1 Jul 2011
Lordkipanidzé Marie, Diodati Jean G, Palisaitis Donald A, Schampaert Erick, Turgeon Jacques, Pharand Chantal
Abstract excerpt
INTRODUCTION: Intersubject variability in platelet response to aspirin could be related to genetic factors that regulate platelet enzymes or receptors. This study evaluates the impact of the selected polymorphisms in the COX-1 gene, the CYP5A1 gene, the P2RY1 receptor gene, and the GPIIbIIIa receptor gene on platelet response to aspirin and risk of suffering from major adverse cardiovascular and cerebrovascular...
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