Article
Influence of cyclooxygenase-1 genotype on ex vivo aspirin response in patients at risk for stroke.
Cerebrovascular diseases (Basel, Switzerland) - 1 Jan 2009
Momary Kathryn M, Shapiro Nancy L, Brace Larry D, Shord Stacy S, Grossi Enzo, Viana Marlos A, Helgason Cathy M, Nutescu Edith A, Cavallari Larisa H
Abstract excerpt
BACKGROUND: We sought to determine whether cyclooxygenase-1 (PTGS1) genotype is associated with the ability of aspirin to inhibit platelet aggregation in patients at risk for stroke. METHODS: Blood and urine samples were collected from 60 subjects, including 28 African Americans, who were taking aspirin for primary or secondary stroke prevention. Samples were analyzed for the PTGS1 A-707G, PTGS1 P17L, and...
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