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Article

Genetic variation in cyclooxygenase 1: Effects on response to aspirin

1 Jan 2003

Abstract excerpt

BACKGROUND: A critical clinical application of the Human Genome Project is to identify functional variation in genes related to disease or responses to xenobiotics. This study moved toward that goal by combining polymorphism detection with functional assays for the therapeutic target gene cyclooxygenase 1 (COX-1). Cyclooxygenase 1 (prostaglandin endoperoxide G/H synthase [PTGS1]) catalyzes the metabolism of...

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Share to Inflammatory mediators and NSAID effects
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PMID: 12545150
DOI: 10.1067/mcp.2003.1

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