Article
A study of LRRK2 mutations and Parkinson's disease in Brazil.
Neuroscience letters - 5 Mar 2008
Pimentel Márcia Mattos Gonçalves, Moura Karla Cristina Vasconcelos, Abdalla Cláudia Bueno, Pereira João Santos, de Rosso Ana Lúcia Zuma, Nicaretta Denise Hack, Campos Mário, de Almeida Richard Morais, dos Santos Jussara Mendonça, Bastos Izabel Cristina Constantino, Mendes Maria Filomena Xavier, Maultasch Henryk, Costa Flavio Henrique de Rezende, Werneck Antônio Luiz dos Santos, Santos-Rebouças Cíntia Barros
Abstract excerpt
Mutations in the Leucine-rich repeat kinase 2 (LRRK2) gene are known as a common cause of Parkinson's disease (PD) among patients from different geographic origins. In this study, we evaluated the prevalence of LRRK2 mutations in exons 31 and 41 in a cohort of 154 consecutive, unrelated Brazilian patients with familial or sporadic PD, including early and late onset patients. The LRRK2 p.G2019S mutation was...
Topics
- Adult
- Age of Onset
- Aged
- Aged, 80 and over
- Antiparkinson Agents
- Brazil
- Cohort Studies
- DNA Mutational Analysis
- Female