Article
LRRK2 G2019S is a common mutation in Spanish patients with late-onset Parkinson's disease.
Neuroscience letters - 13 Mar 2006
Infante Jon, Rodríguez Eloy, Combarros Onofre, Mateo Ignacio, Fontalba Ana, Pascual Julio, Oterino Agustín, Polo José Miguel, Leno Carlos, Berciano José
Abstract excerpt
Mutations in the leucine-rich repat kinase 2 (LRRK2) gene have been shown to cause both autosomal dominant and sporadic Parkinson's disease (PD). The common G2019S mutation shows wide geographical distribution while R1441G has been only reported in Northern Spain. The overall frequency of these mutations remains to be established. To determine the prevalence of G2019S and R1441G mutations in our population of...
Topics
- Age of Onset
- Aged
- Antiparkinson Agents
- Female
- Gene Frequency
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Levodopa
- Male
- Middle Aged
- Mutation