Article
LRRK2 mutations are a common cause of Parkinson's disease in Spain.
European journal of neurology - 1 Apr 2006
Mata I F, Ross O A, Kachergus J, Huerta C, Ribacoba R, Moris G, Blazquez M, Guisasola L M, Salvador C, Martinez C, Farrer M, Alvarez V
Abstract excerpt
Pathogenic mutations in the leucine-rich repeat kinase 2 gene (LRRK2; PARK8) have been implicated in autosomal dominant, late-onset parkinsonism. The LRRK2 6055G > A (G2019S) mutation is the most common reported to date, and has been observed in a number of different European populations. So far, only the LRRK2 4321C > G (R1441G) mutation has been identified in the Spanish population. Herein we have assessed the...
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