Article
LRRK2 mutations are a common cause of Parkinson's disease in Spain.
European journal of neurology - 1 Apr 2006
Mata I F, Ross O A, Kachergus J, Huerta C, Ribacoba R, Moris G, Blazquez M, Guisasola L M, Salvador C, Martinez C, Farrer M, Alvarez V
Abstract excerpt
Pathogenic mutations in the leucine-rich repeat kinase 2 gene (LRRK2; PARK8) have been implicated in autosomal dominant, late-onset parkinsonism. The LRRK2 6055G > A (G2019S) mutation is the most common reported to date, and has been observed in a number of different European populations. So far,...
Topics
- Aged
- DNA Mutational Analysis
- Female
- Genetic Predisposition to Disease
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged
- Mutation
- Parkinson Disease
- Polymorphism, Single Nucleotide
- Protein Serine-Threonine Kinases
- Spain