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Article

Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Sept 2005

Cervo Luigi, Canetta Alessandro, Calcagno Eleonora, Burbassi Silvia, Sacchetti Giuseppina, Caccia Silvio, Fracasso Claudia, Albani Diego, Forloni Gianluigi, Invernizzi Roberto W

Abstract excerpt

Polymorphism of tryptophan hydroxylase, the rate-limiting enzyme in the synthesis of brain serotonin (5-HT), is associated with less synthesis of brain 5-HT in DBA/2J and BALB/c than in C57BL/6J and 129/Sv mice. We selected the forced swimming test, a mouse model used to assess the antidepressant potential of drugs, and neurochemical techniques to study strain differences in the response to citalopram, a...

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Identifiers

PMID: 16148224
DOI: 10.1523/JNEUROSCI.1816-05.2005
PMCID: PMC6725548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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