Article
Effect of glial cell line-derived neurotrophic factor on behavior and key members of the brain serotonin system in mouse strains genetically predisposed to behavioral disorders.
Journal of neuroscience research - 1 Dec 2013
Naumenko Vladimir S, Bazovkina Daria V, Semenova Alina A, Tsybko Anton S, Il'chibaeva Tatyana V, Kondaurova Elena M, Popova Nina K
Abstract excerpt
The effect of glial cell line-derived neurotrophic factor (GDNF) on behavior and on the serotonin (5-HT) system of a mouse strain predisposed to depressive-like behavior, ASC/Icg (Antidepressant Sensitive Cataleptics), in comparison with the parental "nondepressive" CBA/Lac mice was studied. Within 7 days after acute administration, GDNF (800 ng, i.c.v.) decreased cataleptic immobility but increased...
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