Article
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.
Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 2005
Sun Yingli, Jiang Xiaofeng, Chen Shujuan, Fernandes Norvin, Price Brendan D
Abstract excerpt
The ataxia telangiectasia mutant (ATM) protein kinase regulates the cell's response to DNA damage through the phosphorylation of proteins involved in cell-cycle checkpoints and DNA repair. However, the signal-transduction pathway linking DNA strand breaks to activation of ATM's kinase activity is not clearly defined. Here, we demonstrate that DNA damage induces the rapid acetylation of ATM. This acetylation...
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