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Article

Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl

22 Jul 2011

Abstract excerpt

BACKGROUND: The proto-oncogene, c-Abl encodes a ubiquitously expressed tyrosine kinase that critically governs the cell death response induced by genotoxic agents such as ionizing radiation and cisplatin. The catalytic function of Abl, which is essential for executing DNA damage response (DDR), is normally tightly regulated but upregulated several folds upon IR exposure due to ATM-mediated phosphorylation on...

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PMID: 21781306
DOI: 10.1186/1476-4598-10-88

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