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Article

ING5 is a Tip60 cofactor that acetylates p53 in response to DNA damage.

Cancer research - 15 Jun 2013

Liu Nansong, Wang Jiadong, Wang Jifeng, Wang Rukai, Liu Zhongle, Yu Yao, Lu Hong

Abstract excerpt

Posttranslational modification of p53 is a critical event in regulating the expression of its target genes. p53 is acetylated at lysine 120 (K120) by acetyltranferases Tip60 (KAT5) and hMOF (KAT8) in response to DNA damage. Identification of cofactors for these two enzymes will shed light on the mechanism by which cells make a choice between cell-cycle arrest and apoptosis. It has been reported that ING5, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23576563
DOI: 10.1158/0008-5472.CAN-12-3684

Genes

ING5
BAX
KAT5
KAT8

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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