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Article

Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2.

Development (Cambridge, England) - 1 Oct 2004

Thomer Marguerite, May Noah R, Aggarwal Bhagwan D, Kwok Garrick, Calvi Brian R

Abstract excerpt

It is important that chromosomes are duplicated only once per cell cycle. Over-replication is prevented by multiple mechanisms that block the reformation of a pre-replicative complex (pre-RC) onto origins in S and G2 phase. We have investigated the developmental regulation of Double-parked (Dup) protein, the Drosophila ortholog of Cdt1, a conserved and essential pre-RC component found in human and other...

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Identifiers

PMID: 15342466
DOI: 10.1242/dev.01348

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CDK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2.PMID 15342466Read ↗

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