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Article

The cyclin-dependent kinase inhibitor Dacapo promotes replication licensing during Drosophila endocycles.

The EMBO journal - 18 Apr 2007

Hong Amy, Narbonne-Reveau Karine, Riesgo-Escovar Juan, Fu Haiqing, Aladjem Mirit I, Lilly Mary A

Abstract excerpt

The endocycle is a developmentally programmed variant cell cycle in which cells undergo repeated rounds of DNA replication with no intervening mitosis. In Drosophila, the endocycle is driven by the oscillations of Cyclin E/Cdk2 activity. How the periodicity of Cyclin E/Cdk2 activity is achieved during endocycles is poorly understood. Here, we demonstrate that the p21(cip1)/p27(kip1)/p57(kip2)-like...

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Source

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Identifiers

PMID: 17380129
DOI: 10.1038/sj.emboj.7601648
PMCID: PMC1852775

Genes

MCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The cyclin-dependent kinase inhibitor Dacapo promotes replication licensing during Drosophila endocycles.PMID 17380129Read ↗

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Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2.Semantic proximity Read ↗

“The Octet”: Eight Protein Kinases that Control Mammalian DNA ReplicationSemantic proximity Read ↗

Levels of the origin-binding protein Double parked and its inhibitor Geminin increase in response to replication stress.Semantic proximity Read ↗

dpa, a member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila.Semantic proximity Read ↗

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