Article

The Notch ligand Jagged1 plays a dual role in cochlear hair cell regeneration

2025-03-04

Abstract excerpt

<h4>ABSTRACT</h4> Hair cells (HCs) within the inner ear cochlea are specialized mechanoreceptors required for hearing. Cochlear HCs are not regenerated in mammals, and their loss is a leading cause of deafness in humans. Cochlear supporting cells (SCs) in newborn mice have the capacity to regenerate HCs, but persistent Notch signaling, presumably activated by SC-specific Notch ligand Jagged1 (JAG1), prevents SCs...

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Literature Corpus work: ed48ef15-1d29-5230-a458-1db1970674ca
DOI: 10.1101/2025.03.02.640998

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