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Article

Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells.

PloS one - 1 Jan 2014

Savoy-Burke Grace, Gilels Felicia A, Pan Wei, Pratt Diana, Que Jianwen, Gan Lin, White Patricia M, Kiernan Amy E

Abstract excerpt

PURPOSE: To determine whether activated Notch can promote a supporting cell fate during sensory cell differentiation in the inner ear. METHODS: An activated form of the Notch1 receptor (NICD) was expressed in early differentiating hair cells using a Gfi1-Cre mouse allele. To determine the effects of activated Notch on developing hair cells, Gfi1-NICD animals and their littermate controls were assessed at 5 weeks...

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Source

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Identifiers

PMID: 25264928
DOI: 10.1371/journal.pone.0108160
PMCID: PMC4180070

Genes

SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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