Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of Math1 and HES5 in the cochleae of wildtype and Jag2 mutant mice.

Journal of the Association for Research in Otolaryngology : JARO - 1 Sept 2000

Lanford P J, Shailam R, Norton C R, Gridley T, Kelley M W

Abstract excerpt

The sensory epithelium within the mammalian cochlea (the organ of Corti) is a strictly ordered cellular array consisting of sensory hair cells and nonsensory supporting cells. Previous research has demonstrated that Notch-mediated lateral inhibition plays a key role in the determination of cell types within this array. Specificallly, genetic deletion of the Notch ligand, Jagged2, results in a significant increase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cochlea

Share to Embryo, Mammalian

Share to Embryonic and Fetal Development

Share to Mice, Inbred ICR

Share to Mice, Mutant Strains

Source

Open in PubMed Open full text

Identifiers

PMID: 11545143
DOI: 10.1007/s101620010023
PMCID: PMC2504537

Genes

HES5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of Math1 and HES5 in the cochleae of wildtype and Jag2 mutant mice.PMID 11545143Read ↗

Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice.Semantic proximity Read ↗

Notch signalling pathway mediates hair cell development in mammalian cochlea.Semantic proximity Read ↗

The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.Semantic proximity Read ↗

Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial compartment of the developing cochleaSemantic proximity Read ↗

The Notch ligand Jagged1 is required for inner ear sensory development.Semantic proximity Read ↗

The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear.Semantic proximity Read ↗

Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle earSemantic proximity Read ↗

Sox2 is required for sensory organ development in the mammalian inner ear.Semantic proximity Read ↗

Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochlea.Semantic proximity Read ↗

In vivo visualization of Notch1 proteolysis reveals the heterogeneity of Notch1 signaling activity in the mouse cochlea.Semantic proximity Read ↗

Lmx1a is required for segregation of sensory epithelia and normal ear histogenesis and morphogenesis.Semantic proximity Read ↗

Canonical Notch signaling plays an instructive role in auditory supporting cell development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.