Article
Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates.
eLife - 14 Dec 2016
Basch Martin L, Brown Rogers M, Jen Hsin-I, Semerci Fatih, Depreux Frederic, Edlund Renée K, Zhang Hongyuan, Norton Christine R, Gridley Thomas, Cole Susan E, Doetzlhofer Angelika, Maletic-Savatic Mirjana, Segil Neil, Groves Andrew K
Abstract excerpt
The signals that induce the organ of Corti and define its boundaries in the cochlea are poorly understood. We show that two Notch modifiers, Lfng and Mfng, are transiently expressed precisely at the neural boundary of the organ of Corti. Cre-Lox fate mapping shows this region gives rise to inner hair cells and their associated inner phalangeal cells. Mutation of Lfng and Mfng disrupts this boundary, producing...
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