Article
Analysis of intron sequences at the class II HLA-DRB1 locus: implications for the age of allelic diversity.
Hereditas - 1 Jan 1997
Bergström T F, Josefsson A, Erlich H A, Gyllensten U B
Abstract excerpt
Analyses of the coding sequences of HLA class II alleles have revealed high similarity between species, indicating that much of the polymorphism predates the separation of human (Homo) and chimpanzee (Pan), 4-7.4 million years ago. Recent studies of the intron sequences of alleles provide support for a much more recent origin and rapid generation of HLA alleles. At the DRB1 locus, intron analysis indicates that...
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