Article
Restriction of foamy viruses by primate Trim5alpha.
Journal of virology - 1 Jun 2008
Yap Melvyn W, Lindemann Dirk, Stanke Nicole, Reh Juliane, Westphal Dana, Hanenberg Helmut, Ohkura Sadayuki, Stoye Jonathan P
Abstract excerpt
Foamy viruses (FVs) are unconventional retroviruses with a replication strategy that is significantly different from orthoretroviruses and bears some homology to that of hepadnaviruses. Although some cellular proteins, such as APOBEC3, have been reported to block FVs, no restriction by Trim5alpha has been described to date. The sensitivity of three FV isolates of human-chimpanzee or prototypic (PFV), macaque...
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