Article
The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans.
Developmental cell - 1 Sept 2005
Abbott Allison L, Alvarez-Saavedra Ezequiel, Miska Eric A, Lau Nelson C, Bartel David P, Horvitz H Robert, Ambros Victor
Abstract excerpt
The microRNA let-7 is a critical regulator of developmental timing events at the larval-to-adult transition in C. elegans. Recently, microRNAs with sequence similarity to let-7 have been identified. We find that doubly mutant animals lacking the let-7 family microRNA genes mir-48 and mir-84 exhibit retarded molting behavior and retarded adult gene expression in the hypodermis. Triply mutant animals lacking...
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