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Article

Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs.

Cold Spring Harbor symposia on quantitative biology - 1 Jan 2006

Hayes G D, Ruvkun G

Abstract excerpt

The Caenorhabditis elegans microRNAs (miRNAs) lin-4 and let-7 promote transitions between stage-specific events in development by down-regulating the translation of their target genes. Expression of let-7 is required at the fourth larval stage for the proper transition from larval to differentiated, adult fates in the hypodermis; however, it was not known whether expression of let-7 is sufficient to specify these...

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Identifiers

PMID: 17381276
DOI: 10.1101/sqb.2006.71.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs.PMID 17381276Read ↗

The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans.Semantic proximity Read ↗

Functional genomic analysis of the let-7 regulatory network in Caenorhabditis elegans.Semantic proximity Read ↗

let-7 miRNA and lin-46 mRNA are essential targets of the LIN28 RNA-binding protein in Caenorhabditis elegans developmental timing regulation.Semantic proximity Read ↗

Regulatory mutations of mir-48, a C. elegans let-7 family MicroRNA, cause developmental timing defects.Semantic proximity Read ↗

Caenorhabditis elegans period homolog lin-42 regulates the timing of heterochronic miRNA expression.Semantic proximity Read ↗

Multiple cis-elements and trans-acting factors regulate dynamic spatio-temporal transcription of let-7 in Caenorhabditis elegans.Semantic proximity Read ↗

The timing of lin-4 RNA accumulation controls the timing of postembryonic developmental events in Caenorhabditis elegans.Semantic proximity Read ↗

The Caenorhabditis elegans heterochronic gene lin-14 coordinates temporal progression and maturation in the egg-laying system.Semantic proximity Read ↗

Dauer larva quiescence alters the circuitry of microRNA pathways regulating cell fate progression in C. elegans.Semantic proximity Read ↗

<i>let-7</i> controls the transition to adulthood by releasing select transcriptional regulators from repression by LIN41Semantic proximity Read ↗

<i>C. elegans</i> LIN-28 controls temporal cell-fate progression by regulating LIN-46 expression via the 5’UTR of <i>lin-46</i> mRNASemantic proximity Read ↗

The GATA factor elt-1 regulates C. elegans developmental timing by promoting expression of the let-7 family microRNAs.Semantic proximity Read ↗

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