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Article

Upregulation of the let-7 microRNA with precocious development in lin-12/Notch hypermorphic Caenorhabditis elegans mutants.

Developmental biology - 15 Apr 2008

Solomon Aharon, Mian Yousaf, Ortega-Cava Cesar, Liu Victor Won Tat, Gurumurthy Channabasavaiah Basavaraju, Naramura Mayumi, Band Vimla, Band Hamid

Abstract excerpt

The lin-12/Notch signaling pathway is conserved from worms to humans and is a master regulator of metazoan development. Here, we demonstrate that lin-12/Notch gain-of-function (gf) animals display precocious alae at the L4 larval stage with a significant increase in let-7 expression levels. Furthermore, lin-12(gf) animals display a precocious and higher level of let-7 gfp transgene expression in seam cells at L3...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18334253
DOI: 10.1016/j.ydbio.2007.12.046
PMCID: PMC2390880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Upregulation of the let-7 microRNA with precocious development in lin-12/Notch hypermorphic Caenorhabditis elegans mutants.PMID 18334253Read ↗

Functional genomic analysis of the let-7 regulatory network in Caenorhabditis elegans.Semantic proximity Read ↗

Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs.Semantic proximity Read ↗

The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans.Semantic proximity Read ↗

<i>let-7</i> controls the transition to adulthood by releasing select transcriptional regulators from repression by LIN41Semantic proximity Read ↗

The GATA factor elt-1 regulates C. elegans developmental timing by promoting expression of the let-7 family microRNAs.Semantic proximity Read ↗

The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25.Semantic proximity Read ↗

let-756, a C. elegans fgf essential for worm developmentSemantic proximity Read ↗

Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress.Semantic proximity Read ↗

acn-1, a C. elegans homologue of ACE, genetically interacts with the let-7 microRNA and other heterochronic genes.Semantic proximity Read ↗

Regulatory mutations of mir-48, a C. elegans let-7 family MicroRNA, cause developmental timing defects.Semantic proximity Read ↗

The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target.Semantic proximity Read ↗

Multiple cis-elements and trans-acting factors regulate dynamic spatio-temporal transcription of let-7 in Caenorhabditis elegans.Semantic proximity Read ↗

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