Suggestive association between the C825T polymorphism of the G-protein beta3 subunit gene (GNB3) and clinical improvement with antipsychotics in schizophrenia.

doi:10.1016/j.euroneuro.2005.02.001

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Article

Suggestive association between the C825T polymorphism of the G-protein beta3 subunit gene (GNB3) and clinical improvement with antipsychotics in schizophrenia.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Oct 2005

Müller Daniel J, De Luca Vincenzo, Sicard Tricia, King Nicole, Hwang Rudi, Volavka Jan, Czobor Pal, Sheitman Brian B, Lindenmayer Jean-Pierre, Citrome Leslie, McEvoy Joseph P, Lieberman Jeffrey A, Meltzer Herbert Y, Kennedy James L

Abstract excerpt

G-proteins are composed of alpha, beta and gamma subunits. Once activated, these subunits play a major role in the conversion of external receptor activation into intracellular signals. The functional C825T polymorphism of the beta3 subunit gene (GNB3) has recently been shown to modulate antidepressant response, with the T-allele conferring an increased signaling and being associated with favorable antidepressant...

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Identifiers

PMID: 16139171
DOI: 10.1016/j.euroneuro.2005.02.001

Genes

GNB3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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