Article
The genetic variant C825T of the beta 3 subunit of G protein is associated with hypertension in a Portuguese population.
Revista portuguesa de cardiologia - 1 Jun 2018
Sousa Ana Célia, Reis Roberto Palma Dos, Pereira Andreia, Borges Sofia, Gouveia Sara, Spínola Adelaide, Freitas Ana Isabel, Guerra Graça, Góis Teresa, Rodrigues Mariana, Henriques Eva, Ornelas Ilídio, Freitas Carolina, Pereira Décio, Brehm António, Mendonça Maria Isabel
Abstract excerpt
INTRODUCTION: Hypertension is an important public health problem, affecting about 25% of the adult population worldwide.1 Genetic and environmental factors contribute to its pathogenesis. The T allele of the C825T polymorphism of the beta 3 subunit of G protein (rs5443) leads to the production of a truncated variant that enhances intracellular signaling and may interfere with the regulation of blood pressure....
Topics
- Case-Control Studies
- Female
- Genetic Variation
- Heterotrimeric GTP-Binding Proteins
- Humans
- Hypertension
- Male