Article
Evidence for an association between a G-protein beta3-gene variant with depression and response to antidepressant treatment.
Neuroreport - 26 Jun 2000
Zill P, Baghai T C, Zwanzger P, Schüle C, Minov C, Riedel M, Neumeier K, Rupprecht R, Bondy B
Abstract excerpt
Abnormal signal transduction pathways have been implicated in the pathogenesis of bipolar disorder and major depression. G-proteins are key elements of these pathways in the regulation of cellular responses by transmission of signals from receptors to effector proteins. In recent years several studies have reported altered levels and activities of G-protein alpha subunits in depressive patients. A recently...
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