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Article

PKD2 functions as an epidermal growth factor-activated plasma membrane channel.

Molecular and cellular biology - 1 Sept 2005

Ma Rong, Li Wei-Ping, Rundle Dana, Kong Jin, Akbarali Hamid I, Tsiokas Leonidas

Abstract excerpt

PKD2, or polycystin 2, the product of the gene mutated in type 2 autosomal dominant polycystic kidney disease, belongs to the transient receptor potential channel superfamily and has been shown to function as a nonselective cation channel in the plasma membrane. However, the mechanism of PKD2 activation remains elusive. We show that PKD2 overexpression increases epidermal growth factor (EGF)-induced inward...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 16135816
DOI: 10.1128/MCB.25.18.8285-8298.2005
PMCID: PMC1234340

Genes

PKD2
EGF
PIP
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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