Article

Regulation of the PKD2 Channel Function by TACAN

2021-12-24

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in membrane receptor PKD1 or cation channel PKD2. TACAN (also named TMEM120A), recently reported as an ion channel in neuron cells for mechano and pain sensing, is also distributed in diverse non-neuronal tissues such as kidney, heart and intestine, suggesting its involvement in other functions. In this study, we found that TACAN is in com...

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Literature Corpus work: faabff89-aada-52cf-a7dc-89cdc09ac817
DOI: 10.1101/2021.12.23.473878

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