Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin.

Journal of the American Society of Nephrology : JASN - 1 Dec 2009

Kim Ingyu, Ding Tianbing, Fu Yulong, Li Cunxi, Cui Lan, Li Ao, Lian Peiwen, Liang Dan, Wang Dao W, Guo Caiying, Ma Jie, Zhao Ping, Coffey Robert J, Zhan Qimin, Wu Guanqing

Abstract excerpt

Loss of polycystin-2 (PC2) in mice (Pkd2(-/-)) results in total body edema, focal hemorrhage, structural cardiac defects, abnormal left-right axis, hepatorenal and pancreatic cysts, and embryonic lethality. The molecular mechanisms by which loss of PC2 leads to these phenotypes remain unknown. We generated a model to allow targeted Pkd2 inactivation using the Cre-loxP system. Global inactivation of Pkd2 produced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Cysts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Tubules, Collecting

Share to Liver Diseases

Share to Mice, Congenic

Share to Pancreatic Diseases

Share to Polycystic Kidney, Autosomal Dominant

Share to TRPP Cation Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 19939939
DOI: 10.1681/ASN.2009030271
PMCID: PMC2794231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin.PMID 19939939Read ↗

Cardiac defects and renal failure in mice with targeted mutations in Pkd2.Semantic proximity Read ↗

Somatic inactivation of Pkd2 results in polycystic kidney disease.Semantic proximity Read ↗

Molecular and cellular pathogenesis of autosomal dominant polycystic kidney disease.Semantic proximity Read ↗

Human polycystin-2 transgene dose-dependently rescues ADPKD phenotypes in Pkd2 mutant mice.Semantic proximity Read ↗

Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.Semantic proximity Read ↗

Canonical Wnt inhibitors ameliorate cystogenesis in a mouse ortholog of human ADPKD.Semantic proximity Read ↗

Autosomal dominant polycystic kidney disease: clues to pathogenesis.Semantic proximity Read ↗

The Role of the Co-Chaperone DNAJB11 in Polycystic Kidney Disease: Molecular Mechanisms and Cellular Origin of Cyst FormationSemantic proximity Read ↗

Pkd1 and Pkd2 Are Required for Normal Placental DevelopmentSemantic proximity Read ↗

Current advances in molecular genetics of autosomal-dominant polycystic kidney disease.Semantic proximity Read ↗

Polycystin-2 expression is regulated by a PC2-binding domain in the intracellular portion of fibrocystin.Semantic proximity Read ↗

Genetics and Pathogenesis of Polycystic Kidney DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.