Article

Regulation of the PKD2 channel function and associated disease phenotypes by RASSF4

2025-06-26

Abstract excerpt

<title>Abstract</title> <p>ADPKD is caused by mutations in receptor PKD1 and ion channel PKD2. As no effective treatment is available for ADPKD, further studies on the function and regulation of PKD1 and PKD2 are required. Using biotin-neighborhood labeling in HEK293T cells and mass spectrometry analysis, we identified Ras association domain family member-4 (RASSF4) as a potential PKD2-binding protein. Our co-imm...

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Literature Corpus work: d487d466-0f8f-58f9-9d2f-3e0bdc331fb7
DOI: 10.21203/rs.3.rs-6884050/v1

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