Article

PKD2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium

2017-11-07

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in either Pkd1 or Pkd2 result in Autosomal Dominant Polycystic Kidney Disease (ADPKD). Although PKD2 is proposed to be an ion channel subunit, recordings of PKD2 ion channels conflict in their properties. Using a new ADPKD mouse model, we observe primary cilia are abnormally long in cells associated with cysts. Using primary cultures of collecting duct epithelial cells, we show that...

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Literature Corpus work: 0b6aa4a8-e7a9-5c92-be68-551f07c8550c
DOI: 10.1101/215814

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