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Article

Regulation of the PKD2 channel function and associated disease phenotypes by RASSF4.

Communications biology - 15 May 2026

Tian Rui, Fang Wanyi, Yuan Wenbin, Li Shi, Wu Yixin, Dong Xueying, Liu Wei, Kong Jinghua, Deng Xiaoling, Zhang Rui, Lyu Hao, Xiao Shuai, Guo Dong, Zhang Qi, Ali Declan William, Michalak Marek, Zhou Cefan, Tang Jingfeng, Chen Xing-Zhen

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common monogenic genetic disorders, caused by mutations in receptor PKD1 or ion channel PKD2, and is characterized by progressive renal cyst development with additional hepatic and extrarenal manifestations. As effective treatments for ADPKD remain limited, further investigation into the function and regulation of PKD proteins is needed....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42141135
DOI: 10.1038/s42003-026-10242-8
PMCID: PMC13434659

Genes

PKD2
RASSF4
PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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